Topic
Circadian Rhythm
The body's internal 24-hour clock that regulates sleep-wake cycles, hormone release, and metabolism.
Deep Research Articles
How Poor Sleep Accelerates Cognitive Decline: Evidence From 3 Major 2026 Studies
Three landmark 2026 studies — a 13-year CHARLS cohort of 8,900 adults, a PNAS nap/memory experiment, and a Nature Neuroscience GABA/spindle trial — converge on a clear warning: poor sleep doesn't just feel bad, it measurably accelerates cognitive aging.
Beyond Sleep: How Circadian Rhythm Disruption Drives Cancer Progression
Two new studies reveal how circadian rhythm disruption promotes breast cancer and liver cancer progression through molecular mechanisms involving BMAL1, CLOCK, PER3, and lncRNA AC019080.1.
The Brain's Deep-Cleaning System: How Sleep Clears Alzheimer's-Related Toxins
Three new studies reveal how sleep fragmentation impairs glymphatic clearance driven by norepinephrine slow waves, accelerating Aβ accumulation; chronic insomnia independently increases Alzheimer's risk by 31%.
Research Feed
Amber Glasses in the Evening Shift Your Circadian Clock: A Three-Arm RCT
A JAMA Internal Medicine RCT found that wearing amber glasses from 6-9 PM advanced melatonin onset by 45 minutes and improved sleep latency by 12 minutes.
Optimal Melatonin Timing Depends on Your Chronotype
A new study reveals that melatonin's ideal dose and timing vary significantly by chronotype: night owls need 3mg at 2h before bed, early birds respond to 0.5mg at 1h before bed.