Topic
Insomnia
Difficulty falling asleep, staying asleep, or waking too early despite adequate opportunity for sleep.
Deep Research Articles
Research Feed
Shift Work Increases Sleep Disturbance Risk by 58%: Systematic Review of 21,677 People
A 2026 systematic review and meta-analysis in BMC Public Health (22 studies, 21,677 participants from 8 countries) found that shift workers have a 58% higher risk of sleep disturbances compared to regular day workers, with night shifts and rotating shifts posing the highest risk.
A Smartphone App for Insomnia: 42% Remission Rate in Pragmatic Trial of 456 Adults
A pragmatic RCT of 456 adults in The Lancet Digital Health found the SleepFix digital CBT-I app achieved 42% insomnia remission at 8 weeks — sustained at 6 months — rivaling in-person therapy at a fraction of the cost.
IL-17A Identified as Key Inflammatory Mediator in Insomnia
A review reveals IL-17A levels are 2-3× higher in insomnia patients, activating NF-κB in the hypothalamus to disrupt GABAergic sleep circuits — suggesting a new therapeutic target.